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Nick Clegg is set to consult US Vice President Joe Biden on how the coalition Government can improve social mobility in Britain.
The Deputy Prime Minister is keen to learn from Mr Biden about his work on the issue when they meet for lunch at the White House.
While it is outside of his direct remit, Mr Clegg told reporters he would be raising the matter alongside obvious topics for discussion like Afghanistan and Pakistan.
This will be the two deputies' first face-to-face meeting, although they have had a series of discussions via video-calls since May.
Prime Minister David Cameron visited President Barack Obama at the White House in July.
Mr Clegg will be seeking to cement relations between the Conservative-Liberal Democrat coalition and the Obama administration.
The lunch will be the highlight of his visit to Washington, which comes on his first round of high level international diplomacy since taking up the position.
The Lib Dem leader is standing in for Mr Cameron at the United Nations in New York, where he has met UN secretary-general Ban Ki Moon and Iraqi president Jalal Talabani among others.
He has also been attending meetings with charities and aid agencies alongside a string of events on the Millennium Development Goals, rubbing shoulders with the likes of Bob Geldof.
He is scheduled to meet Microsoft billionaire and philanthropist Bill Gates before taking the train to Washington. Mr Clegg is unlikely to meet Mr Obama during the visit to the US as the president is himself attending the UN while the Deputy Prime Minister is in Washington.